Serum Anti-Mullerian Hormone is available test to predict ovarian follicular Status In Infertile Women

In the ovary, Anti-Mulllerian hormone (AMH) is produced by the granulosa cells of early developing follicles. The aim of our study was to assess the value of the AMH as a test to predict ovarian damage in groups of infertile women. Ninety seven infertile women were divided into four groups: (G1=29) with regular menstrual cycle, (G2=30) with prolonged or irregular cycles, (G3=21) with secondary amenorrhea and (G4=17) with polycystic ovarian syndrome or PCOS. A control group of fertile women was included in the study. AMH levels were higher in fertile women than in G1, G2 and G3, but in PCOS women (G4) AMH was higher than in fertile group, reflecting the increased number of small antral follicles in these categories of patients. FSH levels in infertile group were higher in G3 than in G2 and G1 (p=0.002); in fertile women, FSH was (9.2±3.0 UI/ml). There was negative correlation between AMH and age (r=-0.40; p=0.00) and between AMH and FSH, in infertile group. A positive correlation was also found between AMH levels and antral follicle count (AFC) (r=0.6; p=0.00).Our findings suggest that the measurement of AMH seems to be an ideal test for ovarian status which can be assessed in different group of infertile women. Keywords— Anti-Mullerian hormone / Antral follicles count / Infertility / Ovarian reserve / PCOS ——————————  ——————————